A Review Of Conolidine alkaloid for chronic pain
Most recently, it has been discovered that conolidine and the above derivatives act on the atypical chemokine receptor 3 (ACKR3. Expressed in identical regions as classical opioid receptors, it binds to some wide array of endogenous opioids. Unlike most opioid receptors, this receptor acts for a scavenger and will not activate a 2nd messenger metho